Activity-by-Contact Models for Predicting Enhancer-Gene Links

The current standard computational enhancer-gene map; widely used for GWAS variant to gene.

Questions this Concept answers

Why does the ABC model combine an activity term and a contact term instead of using either alone?

jeremy Text

The Activity-by-Contact (ABC) Model for predicting enhancer-gene regulatory interactions —

The Activity-by-Contact model predicts which enhancers regulate which genes in a given cell type by combining two measurable quantities: how active an enhancer is and how often it physically contacts…