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Allele and Haplotype Frequencies in Population Genetics

How the relative frequencies of alleles at a locus, and of haplotypes across linked loci, change under selection, drift, and linkage. Tracking these frequencies over generations is the basic bookkeeping of population genetics and connects genotype composition to differential reproductive success.

Questions this Concept answers

  • Why is linkage disequilibrium defined by comparing observed haplotype frequencies to the product of individual allele frequencies?