An Expression Signal That Lowers ABCC9 in the Adrenal Gland
The concrete link the paper offers: rs2307024-G lowers ABCC9 expression in adrenal gland by 0.64 SD and reduces ascending aortic area by 0.06 SD, while rs704191-T raises pulse pressure by 0.16 SD in a meta-analysis of more than 900,000 Europeans. Students should see that the mechanistic evidence is a set of associations in other traits, not a demonstration in a larynx.
Questions this Concept answers
- An allele at this locus lowers ABCC9 expression in adrenal gland by \( 0.64 \) SD. Why is that a mechanistic hypothesis rather than a demonstration?
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The concrete link the paper offers: rs2307024-G lowers ABCC9 expression in adrenal gland by 0.64 SD and reduces ascending aortic area by 0.06 SD, while rs704191-T raises pulse pressure by 0.16 SD in a meta-analysis of more than 900,000 Europeans. Students should see that the mechanistic evidence is a set of associations in other traits, not a demonstration in a larynx.
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