Atherosclerosis Pathogenesis and Aneurysm Classification
Atherosclerosis is a response to chronic endothelial injury caused by modifiable and non-modifiable risk factors, initiating a cascade involving platelet/macrophage migration into the intima, smooth muscle cell proliferation (neo-intima), and LDL accumulation that forms foam cells. The earliest visible morphological lesion resulting from this pathogenesis is the fatty streak, characterized as an arterial wall lipid deposition distinct from transient physiological changes. This process leads to plaque formation which can rupture or cause complications such as thrombosis, myocardial infarction, aortic dilation (aneurysm), and dissection.
Atherosclerosis: Pathogenesis & Supply/Demand Mismatch – Cardiovascular Pathology | Lecturio
Atherosclerotic plaque formation is a progressive vascular pathology beginning with endothelial injury, which exposes underlying collagen and promotes thrombogenesis, followed by subendothelial accum…