Atherosclerosis Pathogenesis and Aneurysm Classification in Robbins Pathology Chapter 4
Atherosclerosis is a response to chronic endothelial injury caused by modifiable and non-modifiable risk factors, initiating a cascade involving platelet/macrophage migration into the intima, smooth muscle cell proliferation (neo-intima), and LDL accumulation that forms foam cells. The earliest visible morphological lesion resulting from this pathogenesis is the fatty streak, characterized as an arterial wall lipid deposition distinct from transient physiological changes. This process leads to plaque formation which can rupture or cause complications such as thrombosis, myocardial infarction, aortic dilation (aneurysm), and dissection.
Atherosclerosis Pathogenesis and Aneurysm Classification in Robbins Pathology Chapter 4
Atherosclerosis is a response to chronic endothelial injury caused by modifiable and non-modifiable risk factors, initiating a cascade involving platelet/macrophage migration into the intima, smooth …