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Biophysical Dynamical-Systems Model of the C. elegans Premotor Network

A minimally parameterized, connectome-constrained dynamical-systems model in which about fifteen recurrently connected premotor neurons, driven by over a hundred presynaptic sensory and interneurons and tuned to whole-brain imaging and voltage-clamp data, reproduces the nematode's forward-reversal switching, subnetwork synchronization, and behavioral modes, and separates the roles of gap junctions and chemical synapses.

Data Text

2501.00278

This paper builds a biophysical dynamical-systems model of the premotor network that controls C. elegans locomotion. A core group of about fifteen recurrently connected premotor neurons, chosen from …