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CADD as an Integrated Deleteriousness Rank for a Variant

The paper reports CADD 19.01 for the fixed SUR2B missense change. CADD is a trained rank on a scaled distribution, not a measurement, and the node exists so the student can say what the 19.01 is a rank of.

Questions this Concept answers

Why is a CADD value a rank rather than a measurement of anything?

jeremy Text

CADD - Combined Annotation Dependent Depletion

CADD trains a model to separate nearly fixed human-derived variants from simulated mutations, using more than sixty annotations spanning conservation, regulatory, transcript and protein-level evidenc…