Carbodiimide Coupling with Oxyma
DIC activates the acid to an O-acylisourea that is trapped by Oxyma Pure (ethyl cyanohydroxyiminoacetate) as a non-explosive active ester, replacing HOBt/HOAt under transport restrictions. The pair is base-free, which suppresses epimerization and makes it the standard for automated and microwave protocols.
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DIC activates the acid to an O-acylisourea that is trapped by Oxyma Pure (ethyl cyanohydroxyiminoacetate) as a non-explosive active ester, replacing HOBt/HOAt under transport restrictions. The pair is base-free, which suppresses epimerization and makes it the standard for automated and microwave protocols.
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