Catalytic Efficiency
kcat/Km is the apparent second-order rate constant for free enzyme reacting with free substrate at low [S], the right measure for comparing substrates or mutants; values near 10^8-10^9 M^-1 s^-1 indicate a diffusion-limited, catalytically perfect enzyme.
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kcat/Km is the apparent second-order rate constant for free enzyme reacting with free substrate at low [S], the right measure for comparing substrates or mutants; values near 10^8-10^9 M^-1 s^-1 indicate a diffusion-limited, catalytically perfect enzyme.
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