Causes and Pathophysiology of Osteoporosis in Endocrine Pathology
Osteoporosis is an endocrine/skeletal pathology defined as a disorder of compromised bone strength predisposing to fracture, resulting from an imbalance in bone remodeling between osteoblast-mediated formation and osteoclast-mediated resorption. This imbalance is regulated by the RANK/RANK-ligand pathway governing osteoclastogenesis, and is normally restrained by estrogen; loss of estrogen (as in menopause) or age-related decline removes this restraint, shifting the remodeling equilibrium toward excess resorption and progressive trabecular bone loss.
Causes and Pathophysiology of Osteoporosis in Endocrine Pathology
Osteoporosis is an endocrine/skeletal pathology defined as a disorder of compromised bone strength predisposing to fracture, resulting from an imbalance in bone remodeling between osteoblast-mediated…