Chromatin State Segmentation from Combinations of Histone Marks

How annotation atlases summarise many tracks into one; a common lookup layer for variants.

Questions this Concept answers

Why can a single chromatin state annotation, such as strong enhancer, be less certain than it appears at a specific noncoding variant's position?

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Annotating Chromatin States with ChromHMM in Epigenomics

ChromHMM is a computational method in epigenomics that segments the genome into fixed-length bins and applies a hidden Markov model to combinations of epigenomic marks (e.g., histone modifications) c…