Ebola virus disease pathogenicity varies by viral species (Zaire being most lethal, followed by Sudan, Tai Forest, and Reston, which is non-pathogenic to humans but highly pathogenic to monkeys), reflecting species-specific differences in human case fatality rates. Clinical progression follows a defined temporal pattern—an incubation period, an initial non-specific febrile phase, a transient apparent improvement, a hemorrhagic phase marked by coagulopathy, and a terminal cardiovascular shock phase—with infectivity and case fatality rate (ranging broadly by species) increasing as disease progresses, situating this within the domain of viral hemorrhagic fever epidemiology and clinical infectious disease.
Ebola virus disease pathogenicity varies by viral species (Zaire being most lethal, followed by Sudan, Tai Forest, and Reston, which is non-pathogenic to humans but highly pathogenic to monkeys), ref…