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Clinical Signs and Phenotypes of Chronic Obstructive Pulmonary Disease in Respiratory Medicine

Chronic Obstructive Pulmonary Disease (COPD) is a respiratory condition characterized by largely irreversible airflow obstruction, diagnosed via spirometry showing a disproportionately reduced FEV1 relative to FVC, yielding a lowered FEV1/FVC ratio. Clinically, COPD presents along a pathological spectrum between two extremes, distinguished by which underlying pathology (emphysema versus airways obstruction with chronic hypercapnia) predominates, producing distinct clusters of physical signs. This belongs to respiratory medicine, within the study of obstructive airway disease and pulmonary function assessment.