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Coding versus Noncoding Variants and Where GWAS Hits Fall

The motivating fact of the whole path: about 90 percent of hits are noncoding, so mechanism must run through regulation.

Questions this Concept answers

Why does the noncoding location of most GWAS hits point toward gene regulation rather than protein structure?

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Identifying Disease-Causal Genes from Non-Coding GWAS Variants Using 3D Genome Structure

Genome-wide association studies (GWAS) identify statistical associations between genetic variants and disease risk, but most disease-associated variants lie in non-coding regions with no obvious targ…