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Colocalization of GWAS and eQTL Signals

The formal test that a GWAS locus works through a gene's expression. Spine node; distinct from microscopy colocalization.

Questions this Concept answers

Why can a GWAS locus and an eQTL locus overlap in position without truly sharing a causal variant?

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The GWAS-eQTL Colocalization Gap in Human Genetics

Colocalization is a statistical method in human genetics that tests whether a disease-associated GWAS variant and an eQTL variant (a variant that modulates a nearby gene's expression level) share the…