Combinatorial Transcription Factor Binding and Enhancer Grammar

Explains why one motif loss can be buffered or catastrophic depending on context.

Questions this Concept answers

Why can loss of a single transcription factor binding site within an enhancer sometimes have little measurable effect on expression?

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Shavenbaby - Wikipedia

Shavenbaby (svb/ovo) is a Drosophila transcription factor that acts as the master regulator of trichome formation, integrating Hedgehog, EGFR, Wingless, Notch and HOX inputs at seven partly redundant…