Conditional and Joint Analysis for Multiple Signals at One Locus

Allelic heterogeneity is common at strong loci; the student must know to look for a second signal before fine-mapping.

Questions this Concept answers

Why can a locus appear to have only one signal when it actually has two?

jeremy Text

Conditioning analysis

When a GWAS locus shows a broad peak, conditional analysis asks whether the neighbouring associations are just linkage disequilibrium with the lead variant or genuinely independent signals. The metho…