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Cortisol and DHEA Output from the Adrenal Cortex

Supports mechanism hypothesis 1. The adrenal cortex secretes cortisol and the androgen precursor DHEA, and the eQTL effect the paper reports is specifically an adrenal one. DHEA is the term that makes an adrenal route to a sex-hormone-sensitive tissue like the larynx conceivable.

Questions this Concept answers

Why does a change in gene expression measured in the adrenal gland make a route to the larynx conceivable at all?

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Adrenal Gonadocorticoid Synthesis: DHEA and Androstenedione in Endocrinology

This covers the endocrinology of adrenal gonadocorticoid synthesis: the zona reticularis of the adrenal cortex, under hypothalamic-pituitary-adrenal axis stimulation (CRH → ACTH), synthesizes the wea…