CRISPRi Tiling Screens across a GWAS Locus to Map Functional Enhancers

The application that joins the screen branch back to the spine: which element at this locus regulates this gene.

Questions this Concept answers

Why is a CRISPRi tiling screen well suited to mapping functional enhancers across a GWAS locus?

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Functional Genomics Hub

This guide explains how CRISPR interference screens are used to find the functional regulatory elements hidden in a noncoding locus. It covers the mechanism first: a catalytically dead Cas9 fused to …