DNA Methylation Patterns

How adding methyl groups to cytosine bases silences gene expression without changing DNA sequence.

Questions this Concept answers

Why does dense methylation of a gene's promoter CpG island typically silence transcription?

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DNA Methylation and Gene Silencing in Epigenetics

DNA methylation is an epigenetic modification in which DNA methyltransferase enzymes add methyl groups to DNA, regulating gene expression without altering the DNA sequence; its functional effect depe…