DNase-seq and Transcription Factor Footprinting

Enrichment; historical assay behind ENCODE data and a route to bound-factor inference.

Questions this Concept answers

Why does a bound transcription factor create a "footprint" inside a DNase hypersensitive site?

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DNase I Footprinting for Mapping Protein-DNA Binding Sites

DNase I footprinting (DNase hypersensitive sites sequencing / DNase I footprinting assay) is an in vitro biochemical method for mapping protein-DNA binding sites, based on the principle that a protei…