Enhancer-Promoter Communication by Looping Mediator and Cohesin

Mechanistic basis for 3D assays and for distance-independent action.

Questions this Concept answers

Why does cohesin-mediated loop extrusion help explain how an enhancer many kilobases away can contact its target promoter?

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Topologically associating domain

A topologically associating domain is a self-interacting region of a chromosome in which DNA sequences contact each other far more often than they contact sequences outside it. The page explains how …