Conceptual

Explainable Brain Age Gap Estimation with Covariance Neural Networks in Neuroimaging

Uses coVariance Neural Networks (graph neural networks whose graph is the sample covariance matrix, provably equivalent to PCA) on structural-MRI cortical-thickness features to estimate the brain age gap and characterize distinct anatomic patterns across neurodegenerative conditions, with explainability derived from how the network weights eigenvectors of the anatomic covariance matrix.