Finding the Trait-Relevant Cell Type from Single-Cell Data and GWAS Summary Statistics

The single-cell answer to 'which cell type'; joins the GWAS and single-cell branches.

Questions this Concept answers

Why does enrichment of GWAS heritability within a cell type's open chromatin peaks implicate that cell type in the trait?

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scDRS: Linking GWAS Gene Sets to Single-Cell RNA-seq Disease Relevance Scores

scDRS (single-cell disease relevance score) is a computational method linking genome-wide association study (GWAS) gene sets to single-cell RNA-seq data, so that disease association can be scored per…