Fine-Mapping Pitfalls: LD Mismatch Imputation Quality and Allelic Heterogeneity

Analyze/evaluate-level node; the failures that make fine-mapping output confidently wrong.

Questions this Concept answers

Why does poor imputation quality at a variant distort fine-mapping results?

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Modeling and Accounting for LD Reference Mismatch in Summary Statistics Fine-mapping

SuSiE fine-maps a GWAS locus by fitting a sum of single-effect regressions, returning a posterior inclusion probability per variant and grouping variants into credible sets that each likely contain o…