Functionally Informed Fine-Mapping with Regulatory Annotation Priors

Enrichment; joins fine-mapping to annotation, foreshadowing the integration nodes.

Questions this Concept answers

Why can adding a functional annotation prior improve fine-mapping precision?

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Zoonomia: Evolutionary Constraint Across 240 Mammalian Genomes for GWAS Fine-Mapping

Evolutionary constraint analysis (comparative genomics) infers which genomic positions are functionally important by measuring cross-species sequence conservation: greater phylogenetic branch length …