Genetic Correlation rg Between Two Traits
Deepest node of the sub-domain: it consumes two sets of summary statistics through LD score regression and returns whether the same variants move two traits in the same direction. The seed paper reports r_g = 0.30 between educational attainment and pitch variability and r_g = -0.20 between smoking and pitch, and both are extremely easy to misread as causal, which is exactly what the honest-reading section then handles.
Questions this Concept answers
- Why does a nonzero \( r_{g} \) fail to establish that one trait causes the other?
LD Score Regression for Genetic Correlation in Statistical Genetics
LD score regression extends from genome-wide SNP heritability to partitioned heritability, where per-SNP effect-size variance depends on functional/genomic annotations, using per-annotation LD scores…