Browse Teach Curate

Genome Coordinates Assembly Builds and Liftover between GRCh37 and GRCh38

Mismatched builds between summary statistics, LD panels, and annotations are the most common silent failure when overlapping data sources.

Questions this Concept answers

Why can the same variant have different coordinate numbers in GRCh37 versus GRCh38?

jeremy Video

Determining the Genome Build (Hg19/GRCh37 vs Hg38/GRCh38) of a GWAS Dataset in Genomics

In genomics, a "reference genome build" (e.g., hg19/GRCh37, hg38/GRCh38) is a versioned coordinate system assigning chromosome-and-position addresses to genetic variants; because successive builds re…