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Genome-Wide Significance and the 5 x 10^-8 Threshold

A number every student will quote; the node makes them derive it and see when it is wrong (rare variants, other ancestries).

Questions this Concept answers

Why is the genome-wide significance threshold set so much stricter than the conventional \( p < 0.05 \) used in single-hypothesis testing?

jeremy Text

GWAS Genome-Wide Significance Thresholds

Genome-wide significance is the multiple-testing bar a GWAS must clear because it runs one association test per SNP across hundreds of thousands to millions of variants. The conventional p < 5 x 10^-…

Genome-Wide Significance and the 5 x 10-8 Threshold

Questions this Concept answers

GWAS Genome-Wide Significance Thresholds

Genome-Wide Significance and the 5 x 10^-8 Threshold