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Genotype Imputation from a Haplotype Reference Panel

Fills the array to millions of variants and is where LD panels enter the pipeline. Imputation quality is a fine-mapping pitfall later.

Questions this Concept answers

Why does imputation rely on a haplotype reference panel rather than each sample alone?

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Rapid Genotype Imputation with Millions of Reference Samples in Population Genetics

Genotype imputation is the statistical inference of unobserved genetic markers in a target sample by comparing its sparse genotyped haplotypes against a dense reference panel of sequenced haplotypes,…