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Haplotype Phasing

How variants are assigned to the chromosome copy they came from, and why a phased block ends where the evidence linking consecutive variants runs out.

Questions this Concept answers

Why do reference-panel-based imputation methods require phased haplotypes rather than raw unphased genotypes?

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Genotype Phasing to Determine Haplotype Chromosome of Origin

Genotyping (array-based probing of known variant positions) and sequencing (reading the full genome to detect both known and novel variants) are two complementary technologies for measuring genetic v…