Hard Versus Soft Ionization
Electron ionization deposits far more energy than the ionization threshold and yields rich, reproducible fragmentation but often no molecular ion; electrospray and MALDI transfer intact ions with little internal energy and give molecular-weight information but few fragments. Which method was used determines whether a spectrum should be read for structure or for mass.
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Electron ionization deposits far more energy than the ionization threshold and yields rich, reproducible fragmentation but often no molecular ion; electrospray and MALDI transfer intact ions with little internal energy and give molecular-weight information but few fragments. Which method was used determines whether a spectrum should be read for structure or for mass.
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