Hidden Confounders in Expression Data and Latent Factor Correction

Enrichment; why eQTL pipelines include dozens of latent covariates.

Questions this Concept answers

Why do hidden confounders pose a bigger problem for eQTL mapping than for GWAS of disease traits?

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PCA Outperforms PEER SVA and HCP for Hidden Confounder Inference in Molecular QTL Mapping

Hidden variable (hidden confounder) inference is the problem, in molecular quantitative trait locus (QTL) mapping, of estimating unmeasured confounding factors from a sample-by-molecular-phenotype ma…