HMBC Experiment
HMBC shows proton-to-carbon correlations across 2-3 bonds while suppressing one-bond peaks, so it reaches carbons with no attached protons: carbonyls, quaternary and heteroatom-bearing centers. It is the experiment that joins fragments across the 'silent' atoms COSY and HSQC cannot cross.
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HMBC shows proton-to-carbon correlations across 2-3 bonds while suppressing one-bond peaks, so it reaches carbons with no attached protons: carbonyls, quaternary and heteroatom-bearing centers. It is the experiment that joins fragments across the 'silent' atoms COSY and HSQC cannot cross.
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