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Human Germline Editing Ethics

Somatic edits affect one patient; germline edits in embryos are heritable, made without the subject's consent, and are complicated by mosaicism and unverifiable off-target risk. The He Jiankui case established the current international consensus against clinical germline use.

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Somatic edits affect one patient; germline edits in embryos are heritable, made without the subject's consent, and are complicated by mosaicism and unverifiable off-target risk. The He Jiankui case established the current international consensus against clinical germline use.

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