Immunomodulators and immunosuppressives function by altering immune system activity to address pathological states such as allergies, autoimmune disorders, or allograft rejection through the modulation of cytokine production and lymphocyte proliferation. The core theoretical framework distinguishes between immunsimulants that enhance resistance via antigen presentation and specific agents like corticosteroids, cytotoxic antiproliferatives, biologics, and conventional immunosuppressants that suppress adaptive immunity to prevent tissue destruction or graft loss. Within pharmacology, this theory relies on the formal definition of immunomodulation as a regulatory process balancing host defense capabilities against the risks of infection and malignancy associated with broad immune suppression.
Immunomodulators and immunosuppressives function by altering immune system activity to address pathological states such as allergies, autoimmune disorders, or allograft rejection through the modulati…