Inferring an Enhancer-Driven Gene Regulatory Network from Multiome Data

Closing node of sketch 4; the object that names TF, enhancer, and gene together.

Questions this Concept answers

Why does inferring this kind of network require multiome data (paired chromatin accessibility and gene expression from the same cells) rather than expression data alone?

jeremy Text

SCENIC+: single-cell multiomic inference of enhancers and gene regulatory networks

An enhancer-driven gene regulatory network (eGRN) is the object that names a transcription factor, the specific enhancer it binds, and the gene that enhancer controls, all together. Building one from…