Introducing a Single Variant with Base Editing Prime Editing or HDR

The variant-level gold standard: change one base and measure.

Questions this Concept answers

Why is prime editing described as a search-and-replace tool for introducing precise variants?

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Prime Editing Using pegRNA and nCas9 in Genome Editing

Prime editing is a genome editing approach that overcomes the limitation of base editing (restricted to specific base transitions and unable to perform arbitrary transversions, insertions, or deletio…