Irreversible Enzyme Inhibition
A covalent or extremely tight-binding inactivator removes enzyme permanently, so activity decays with time and is described by kinact/KI rather than by a Ki; mechanism-based suicide inhibitors require catalytic turnover to unmask the reactive group.
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A covalent or extremely tight-binding inactivator removes enzyme permanently, so activity decays with time and is described by kinact/KI rather than by a Ki; mechanism-based suicide inhibitors require catalytic turnover to unmask the reactive group.
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