Isogenic Cell Lines and iPSC-Derived Models for Variant Testing

Where single-variant edits are done and why the cell type has to be right.

Questions this Concept answers

Why are iPSC-derived models often chosen over immortalized cell lines for testing a regulatory variant's effect?

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CRISPR-Based Functional Genomics in iPSC Models of Brain Disease

CRISPR-based functional genomics addresses the gap between genome-wide association studies (which identify genetic variants linked to disease or traits) and mechanistic understanding, by using progra…