LD Blocks Recombination Hotspots and Haplotype Structure

Defines the physical extent of a GWAS locus and why ancestry changes it. Sets up trans-ancestry fine-mapping.

Questions this Concept answers

Why do LD blocks differ in size across human ancestry groups?

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SNPs, Linkage Disequilibrium, and Haplotypes in Genetics

Genetic polymorphism refers to loci (genomic positions) with alleles (sequence variants) whose minor allele frequency exceeds 1% in a population, with single nucleotide polymorphisms (SNPs) — arising…