Lead Variants Loci and Clumping a GWAS into Independent Signals

Turns a Manhattan plot into a list of loci. The object the rest of the path traces.

Questions this Concept answers

Why does clumping group multiple genome-wide significant variants into a single independent locus rather than counting each as a separate discovery?

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Mapping Disease Genes with Linkage Analysis and Genome-Wide Association Studies in Human Genetics

Human genetics maps disease-associated genetic loci by exploiting patterns of inheritance: linkage analysis identifies co-segregation of rare, high-penetrance variants within families along a chromos…