Linear Mixed Models and Genetic Relatedness in Association Testing

How biobank-scale GWAS are actually run. Enrichment for students who will run one.

Questions this Concept answers

Why do biobank-scale GWAS commonly use linear mixed models instead of plain linear regression?

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Mixed Linear Models for Inbreeding and Population Structure in GWAS

Genome-wide association studies (GWAS) require correction for non-independence among samples—arising from population structure, inbreeding, cryptic relatedness, and batch effects—because naive regres…