Liquid Chromatography-Mass Spectrometry
Reversed-phase LC delivers non-volatile and thermally fragile analytes into an electrospray source, giving protonated or deprotonated molecules that are then fragmented by MS/MS. Ion suppression from co-eluting matrix means chromatographic separation directly controls quantitative accuracy.
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Reversed-phase LC delivers non-volatile and thermally fragile analytes into an electrospray source, giving protonated or deprotonated molecules that are then fragmented by MS/MS. Ion suppression from co-eluting matrix means chromatographic separation directly controls quantitative accuracy.
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