Massively Parallel Reporter Assays for Testing Thousands of Variants

Scales the reporter assay to a whole credible set; the standard variant-level functional screen.

Questions this Concept answers

Why does an MPRA test variants inside a reporter construct rather than editing them directly in the genome?

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Massively Parallel Reporter Assays for Analyzing Non-Coding Variants in Autism Genomics

Massively parallel reporter assays (MPRAs) can be applied to functionally characterize non-coding genetic variants by comparing reporter gene expression driven by the reference allele versus the alte…