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Max-Cut Unitig Phasing for Parent-Free Haplotype-Resolved Assembly

How casting the phase assignment of heterozygous unitigs in a long-read assembly graph as a graph max-cut problem, weighted by Hi-C link likelihoods or by trans read overlaps, yields both haplotypes of a diploid genome from a single individual without sequencing the parents.

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Robust haplotype-resolved assembly of diploid individuals without parental data

Haoyu Cheng and Heng Li (Dana-Farber Cancer Institute and Harvard Medical School) with Erich D. Jarvis and Olivier Fedrigo (Vertebrate Genome Lab, Rockefeller University and HHMI), Klaus-Peter Koepfl…