Mechanisms and Treatment of Peptic Ulcer Disease in Gastroenterology
Peptic ulcer disease (PUD) is a gastroenterology condition defined by mucosal erosion of the stomach or duodenum, arising from an imbalance between mucosal-protective factors (bicarbonate, prostaglandins) and injurious factors (acid, pepsin, bile, NSAIDs, H. pylori). Gastric PUD is primarily driven by impaired mucosal defense despite normal acid levels, while duodenal PUD is primarily driven by excess acid delivery, distinguishing the two subtypes by pathogenesis, complication risk, and malignant potential. Treatment centers on acid suppression, mucosal protection, and eradication of H. pylori when present.
Mechanisms and Treatment of Peptic Ulcer Disease in Gastroenterology
Peptic ulcer disease (PUD) is a gastroenterology condition defined by mucosal erosion of the stomach or duodenum, arising from an imbalance between mucosal-protective factors (bicarbonate, prostaglan…