Conceptual
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Mechanisms of Diarrhea in Gastrointestinal Pathology

Diarrhea is classified in gastrointestinal pathology by its underlying mechanism: osmotic (unabsorbed solutes drawing water into the intestinal lumen), secretory (active fluid secretion into the lumen), altered motility, and exudative (inflammatory/ischemic loss of mucosal integrity). This mechanistic classification guides identification of the causative process and anticipation of complications, notably metabolic acidosis from bicarbonate loss and hypokalemia from excessive stool losses. The topic sits within gastrointestinal pathophysiology, linking clinical presentation to underlying disease process.