Microwave-Assisted Peptide Synthesis
Dielectric heating to 75-90 C cuts coupling times to a few minutes and improves access to aggregated chains, at the cost of higher epimerization risk for Cys and His, which are coupled at reduced temperature. Modern instruments pair it with low-volume flow washing to cut solvent consumption sharply.
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Dielectric heating to 75-90 C cuts coupling times to a few minutes and improves access to aggregated chains, at the cost of higher epimerization risk for Cys and His, which are coupled at reduced temperature. Modern instruments pair it with low-volume flow washing to cut solvent consumption sharply.
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