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Minor Allele Frequency and Common versus Rare Variants

MAF determines power, imputation quality, and whether a variant is even on an array. Atomic and reused constantly downstream.

Questions this Concept answers

Why does low MAF reduce a GWAS's power to detect an association?

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Minor allele frequency

Minor allele frequency is the frequency of the second most common allele at a variable site in a population, computed by counting allele copies across diploid genotypes and dividing by twice the numb…