Mixed Inhibition
The inhibitor binds both E and ES with distinct constants Ki and Ki', lowering Vmax while shifting Km up or down depending on which affinity is greater; pure noncompetitive inhibition is the special case Ki = Ki', where Km is untouched.
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The inhibitor binds both E and ES with distinct constants Ki and Ki', lowering Vmax while shifting Km up or down depending on which affinity is greater; pure noncompetitive inhibition is the special case Ki = Ki', where Km is untouched.
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